Logopharm in the press

• "Complex issues relating to membranes"

  BioPro portal | Jul 11, 2010 | English (German version)

• "From protein complexes to networks"

  BioPro portal | Oct 17, 2008 | English (German version)

• "Membrane Protein Challenge"

  Chemische Rundschau magazine | Sep 12, 2008 | English

Editorials, campaigns, application notes

• "Protein Complexes – Challenges and Opportunities for Drug Discovery"

  White Paper | Next Generation Pharmaceuticals Europe/USA 2008 | English

• "Omes and omics"

  Interview | Next Generation Pharmaceuticals Europe (285) 2008 | English

• Target R&D Services

  Advertisement | 2011 | English

Scientific publications

High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B. Neuron 2012; 74(4):621-33. PMID 22632720

GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(−) channel auxiliary subunit. Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R. Neuron 2012; 73(5):951-61. PMID 22405205

Extending The Dynamic Range Of Label-Free Mass Spectrometric Quantification Of Affinity Purifications. Bildl W, Haupt A, Mueller CS, Biniossek ML, Thumfart JO, Hueber B, Fakler B, Schulte U. Mol Cell Proteomics 2012; 11(2):M111.007955. Epub 2011 Nov 8. PMID 22067099

Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism. López-Hernández T, Ridder MC, Montolio M, Capdevila-Nortes X, Polder E, Sirisi S, Duarri A, Schulte U, Fakler B, Nunes V, Scheper GC, Martínez A, Estévez R, van der Knaap MS. Am J Hum Genet 2011; 88(4):422-32. PMID 21419380

Ion channels and their molecular environments - Glimpses and insights from functional proteomics. Schulte U, Müller C, Fakler B. Semin Cell Dev Biol. 2011; 22(2):132-44. PMID 20934526

Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U. Proc Natl Acad Sci USA 2010; 107(34):14950-7. PMID 20668236

Ca2+-Activated K+ Channels: From Protein Complexes to Function. Berkefeld, H., Fakler, B., Schulte, U. Physiological Reviews 2010; 90(4):1437-59. PMID 20959620

Native GABA(B) receptors are heteromultimers with a family of auxiliary subunits. Schwenk J, Metz M, Zolles G, Turecek R, Fritzius T, Bildl W, Tarusawa E, Kulik A, Unger A, Ivankova K, Seddik R, Tiao JY, Rajalu M, Trojanova J, Rohde V, Gassmann M, Schulte U, Fakler B, Bettler B. Nature 2010; 465(7295):231–5. PMID 20400944

Polycystin-1 and -2 Dosage Regulates Pressure Sensing. Sharif-Naeini R, Folgering JHA, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJM, Honore E. Cell 2009; 139(3):587–96. PMID 19879844

Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller C, Thumfart JO, Pfeifer A, Fleischmann BK, Fakler B, Klöcker N. Neuron 2009; 62(6):814-25. PMID 19555650

Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N. Science 2009; 323(5919):1313-9. PMID 19265014

Profiling the phospho-status of the BKca channel a subunit in rat brain reveals unexpected patterns and complexity. Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS. Mol Cell Proteomics 2008; 7(11):2188-98. PMID 18573811

Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Proc Natl Acad Sci USA 2008; 105(32):11140-5. PMID 18682566

Protein-protein interactions and subunit composition of ion channels. Schulte U. CNS Neurol Disord Drug Targets 2008; 7(2):172-86. PMID 18537645

BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B. Science 2006; 314(5799):615-20. PMID 17068255

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B. Neuron 2006; 49(5):697-706. PMID 16504945

Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating. Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B. Neuron 2004; 43(6): 847-58. PMID 15363395